michaelahenson4

    • Free Release of MediumFBA Version 2.0

    We are pleased to announce the free release of MediumFBA version 2.0, a a MATLAB application that integrates the medium design and flux balance analysis (FBA) problems to allow more efficient analysis of metabolic models.

    Originally released in February 2024, MediumFBA generates growth media that ensure monoculture growth of all included strains, where the metabolic properties of each strain is captured with an available genome-scale reconstruction. The workflow allows the definition of nutrients to be included and excluded from the medium such that the user can guide the medium design algorithm to yield an acceptable solution. The designed medium can be modified by the user to explore the effects of nutrient uptake rates and non-essential nutrients on monoculture growth, nutrient utilization and product secretion patterns.

    MediumFBA version 2.0 provides the following new capabilities over previous releases:

    • The ability to generate, store and compare multiple FBA result sets simulated with different metabolic models and/or media formulations.
    • The ability to plot selected nutrient and product fluxes for any combination of models and any result set.

    More information about MediumFBA and the freely downloadable application are available here.