Genome-scale metabolic modeling allows a sequenced genome to be translated into a mathematical model of the interacting metabolic pathways that determine the phenotypic behavior of the sequenced strain. With the development of increasingly sophisticated reconstruction pipelines, metabolic modeling has become an established academic research tool. However, the lack of experienced practitioners and focused modeling groups has slowed penetration into biotechnology and biomedical industries. We believe that metabolic modeling represents a powerful complimentary technology to standard experimental and bioinformatic methods that has the potential to accelerate innovation, discovery and manufacturing.
We aim to bridge the gap between academic research and industrial practice using our vast experience in metabolic modeling of microbial systems and fermentation processes. Our novel approach allows the same models used for detailed metabolic analysis of individual microbes to be integrated within larger scale system and process models to maximize modeling effort, value and impact. Our expertise can be impact your organization through a variety of collaboration options, including employee training, app development, proprietary consulting, and collaborative research. We offer particular strength in the following areas:
- Reconstruction and refinement of genome-scale metabolic models
- Flux balance analysis and related constraint-based analysis methods
- In silico metabolic engineering for metabolite overproduction
- Dynamic simulation of stirred tank biochemical reactors
- Simulation of synthetic and host-associated microbial communities
Please contact us by email if you would like to learn more about any of these areas of expertise.
