Metabolic modeling for microbial processes

Applying microbial system principles to challenges ranging from renewable chemical production to microbiota-associated diseases

I am passionate about translating recent advances in microbial metabolic modeling to industrial practice. I believe that in silico modeling can accelerate innovation and expand applications of microbial technologies that benefit society.

About In Silico Fermentation
Expertise and Capabilities

Innovation across diverse microbial systems and processes

Bioreactor Process Engineering

Dynamic metabolic models for fermentation process simulation, estimation, control and optimization

Gas Fermentation

Combined metabolic-transport models of bubble column bioreactors for upgrading waste gases to platform chemicals

Mixed Microbial Cultures

Multispecies metabolic models to design, simulate and optimize microbial consortia for diverse bioconversion applications

Multispecies Biofilms

Spatiotemporal metabolic models to predict species organization and interaction in natural and engineered biofilms

Human Gut Microbiome

Community metabolic models to translate measured taxa compositions into predicted metabolic capabilities

Disease-Associated Communities

Sample-specific metabolic models to differentiate healthy and disease states in diverse human microbiomes

Collaboration and Partnerships

Customized consulting, research and development, and training solutions

Experience and Accomplishments

Important contributions to engineering applications of metabolic modeling

Mike Henson

Founder and Principal

News and Updates

Updates on the exciting progess of In Silico Fermentation!

Free Release of MediumFBAtutorial MATLAB Application

In Silico Fermentation is pleased to announce the release of MediumFBAtutorial, a free MATLAB application that provides two tutorials that demonstrate the use of our MediumFBA app for integrated medium design and flux balance analysis (FBA). Using genome-scale metabolic reconstructions from the AGORA resource, users are guided through an intuitive workflow in which they identify […]

Free Release of MediumFBA Version 2.0

We are pleased to announce the free release of MediumFBA version 2.0, a a MATLAB application that integrates the medium design and flux balance analysis (FBA) problems to allow more efficient analysis of metabolic models. Originally released in February 2024, MediumFBA generates growth media that ensure monoculture growth of all included strains, where the metabolic […]

Free Release of BacMicroSim Version 1.0

In Silico Fermentation has been developing freely downloadable MATLAB applications that streamline the utilization of microbial metabolic modeling methods. To date, we have released four research oriented apps (MediumFBA, InSilicoKO, STBRsim, SynComSim), and one educationally focused app (STBRtutorial). Now we are pleased to announce the release of BacMicroSim, a free MATLAB application that enables rapid […]

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