Metabolic modeling for microbial processes

Applying microbial system principles to challenges ranging from renewable chemical production to microbiota-associated diseases

I am passionate about translating recent advances in microbial metabolic modeling to industrial practice. I believe that in silico modeling can accelerate innovation and expand applications of microbial technologies that benefit society.

About In Silico Fermentation
Expertise and Capabilities

Innovation across diverse microbial systems and processes

Bioreactor Process Engineering

Dynamic metabolic models for fermentation process simulation, estimation, control and optimization

Gas Fermentation

Combined metabolic-transport models of bubble column bioreactors for upgrading waste gases to platform chemicals

Mixed Microbial Cultures

Multispecies metabolic models to design, simulate and optimize microbial consortia for diverse bioconversion applications

Multispecies Biofilms

Spatiotemporal metabolic models to predict species organization and interaction in natural and engineered biofilms

Human Gut Microbiome

Community metabolic models to translate measured taxa compositions into predicted metabolic capabilities

Disease-Associated Communities

Sample-specific metabolic models to differentiate healthy and disease states in diverse human microbiomes

Collaboration and Partnerships

Customized consulting, research and development, and training solutions

Experience and Accomplishments

Important contributions to engineering applications of metabolic modeling

Mike Henson

Founder and Principal

News and Updates

Updates on the exciting progess of In Silico Fermentation!

Free Release of InSilicoKO MATLAB Application

In Silico Fermentation is pleased to announce the release of InSilicoKO version 2.0, a freely downloadable MATLAB application for the computational design of knockout strains for metabolite overproduction based on genome-scale metabolic reconstructions. The GUI tool provides a simple and intuitive workflow that allows the user to generate reaction/gene knockouts that maximize the secretion of […]

MediumFBA Version 1.1 Now Freely Downloadable

Early this month, In Silico Fermentation released MediumFBA version1.0, a freely downloadable MATLAB application for genome-scale metabolic modeling. MediumFBA is a GUI tool which generates growth media that ensure monoculture growth of all strains through a simple and intuitive workflow. We are gratified that MediumFBA already has over 60 downloads. Based on initial user feedback, […]

Free Release of MediumFBA MATLAB Application

In Silico Fermentation is pleased to announce the release of MediumFBA version1.0, a freely downloadable MATLAB application that integrates the medium design and flux balance analysis (FBA) problems to facilitate in silico metabolic analyses. MediumFBA is a GUI tool which generates growth media that ensure monoculture growth of all strains where the metabolic properties of […]

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