Metabolic modeling for microbial processes

Applying microbial system principles to challenges ranging from renewable chemical production to microbiota-associated diseases

I am passionate about translating recent advances in microbial metabolic modeling to industrial practice. I believe that in silico modeling can accelerate innovation and expand applications of microbial technologies that benefit society.

About In Silico Fermentation
Expertise and Capabilities

Innovation across diverse microbial systems and processes

Bioreactor Process Engineering

Dynamic metabolic models for fermentation process simulation, estimation, control and optimization

Gas Fermentation

Combined metabolic-transport models of bubble column bioreactors for upgrading waste gases to platform chemicals

Mixed Microbial Cultures

Multispecies metabolic models to design, simulate and optimize microbial consortia for diverse bioconversion applications

Multispecies Biofilms

Spatiotemporal metabolic models to predict species organization and interaction in natural and engineered biofilms

Human Gut Microbiome

Community metabolic models to translate measured taxa compositions into predicted metabolic capabilities

Disease-Associated Communities

Sample-specific metabolic models to differentiate healthy and disease states in diverse human microbiomes

Collaboration and Partnerships

Customized consulting, research and development, and training solutions

Experience and Accomplishments

Important contributions to engineering applications of metabolic modeling

Mike Henson

Founder and Principal

News and Updates

Updates on the exciting progess of In Silico Fermentation!

In Silico Fermentation MATLAB Apps Reach 2500 Downloads

We are pleased to report that our suite of free MATLAB applications that provide state-of-the-art microbial metabolic modeling and simulation tools has surpassed 2500 downloads. Our hope is that these apps will allow industrial practitioners, academic researchers, and biotechnology educators to take full advantage of the power of metabolic modeling without the need to grapple […]

Training Course on Genome-Scale Metabolic Reconstructions and Flux Balance Analysis

In Silico Fermentation is pleased to announce our first training course focused on genome-scale metabolic reconstructions and their use for constraint-based metabolic analysis. The training focuses on developing a functional knowledge of metabolic reconstructions and more in-depth understanding of flux balance analysis (FBA) and its most important variants. Key concepts are demonstrated through computational exercises […]

Free Release of MediumFBAtutorial MATLAB Application

In Silico Fermentation is pleased to announce the release of MediumFBAtutorial, a free MATLAB application that provides two tutorials that demonstrate the use of our MediumFBA app for integrated medium design and flux balance analysis (FBA). Using genome-scale metabolic reconstructions from the AGORA resource, users are guided through an intuitive workflow in which they identify […]

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