Flux Balance Analysis (FBA) has proven to be a very valuable tool for predicting microbial metabolism. However, FBA neglects dynamic process behavior and does not provide predictions of extracellular variables. Both these capabilities are critical for fermentation process modeling. Dynamic flux balance modeling is a powerful extension that combines steady-state cell metabolism with extracellular dynamics […]

Microbiota metabolic modeling is a powerful complementary tool to experimentation for interrogating microbial communities involved in human disease. One of my recent review papers overviews some of the capabilities, accomplishments and challenges associated with bacterial community modeling. In Silico Fermentation offers metabolic modeling tools to simulate, analyze and manipulate host-associated microbiota involved in human health […]

Fermentation modeling is no simple task. Key to any successful project is to determine the desired level of modeling detail, selecting an appropriate model structure, executing well-designed experiments, performing model parameter estimation using the available data, conducting model validation studies, deploying the model for real-time use, training operations staff, and maintaining the model application. It […]

In Silico Fermentation was created to support the biotechnology and biomedical industries by providing consulting services, applied research, and educational training on microbial systems and processes. The company was founded by Dr. Mike Henson following his 28-year academic career as a vehicle to translate recent advances in metabolic modeling to industrial practice. A novel computational […]