Free Release of MediumFBA MATLAB Application

In Silico Fermentation is pleased to announce the release of MediumFBA version1.0, a freely downloadable MATLAB application that integrates the medium design and flux balance analysis (FBA) problems to facilitate in silico metabolic analyses.

MediumFBA is a GUI tool which generates growth media that ensure monoculture growth of all strains where the metabolic properties of each strain is captured with an available genome-scale reconstruction. The GUI provides a simple and intuitive workflow that allows the user to construct minimal growth media and to perform FBA calculations without the usual practice of writing and debugging MATLAB code.

The workflow allows the definition of nutrients to be included and excluded from the medium such that the user can guide the medium design algorithm to yield an acceptable solution. The designed medium can be modified by the user to explore the effects of nutrient uptake rates and non-essential nutrients on monoculture growth and product secretion patterns.

More information about MediumFBA and the freely downloadable application are available here.